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Literature summary for 3.5.4.25 extracted from

  • Anam, K.; Nasuno, R.; Takagi, H.
    A novel mechanism for nitrosative stress tolerance dependent on GTP cyclohydrolase II activity involved in riboflavin synthesis of yeast (2020), Sci. Rep., 10, 6015.
    View publication on PubMed
Search for more literature for 3.5.4.25

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
GTP + 4 H2O Saccharomyces cerevisiae
-
 formate + 2,5-diamino-6-hydroxy-4-(5-phospho-D-ribosylamino)pyrimidine + 2 phosphate
-
 ?
GTP + 4 H2O Saccharomyces cerevisiae ATCC 204508
-
 formate + 2,5-diamino-6-hydroxy-4-(5-phospho-D-ribosylamino)pyrimidine + 2 phosphate
-
 ?

Organism

Organism UniProt Comment Textmining
Saccharomyces cerevisiae P38066
-
-
Saccharomyces cerevisiae ATCC 204508 P38066
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
GTP + 4 H2O
-
 Saccharomyces cerevisiae formate + 2,5-diamino-6-hydroxy-4-(5-phospho-D-ribosylamino)pyrimidine + 2 phosphate
-
 ?
GTP + 4 H2O
-
 Saccharomyces cerevisiae ATCC 204508 formate + 2,5-diamino-6-hydroxy-4-(5-phospho-D-ribosylamino)pyrimidine + 2 phosphate
-
 ?

Synonyms

Synonyms Comment Organism
GTPCH2
-
 Saccharomyces cerevisiae
RIB1
-
 Saccharomyces cerevisiae

General Information

General Information Comment Organism
metabolism the enzyme catalyzes the first step in riboflavin biosynthesis Saccharomyces cerevisiae
physiological function GTPCH2 enzymatic activity of Rib1 is essential for RIB1-dependent nitrosative stress tolerance Saccharomyces cerevisiae