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Literature summary for 3.5.4.16 extracted from

  • Du, Y.H.; Guan, Y.Y.; Alp, N.J.; Channon, K.M.; Chen, A.F.
    Endothelium-specific GTP cyclohydrolase I overexpression attenuates blood pressure progression in salt-sensitive low-renin hypertension (2008), Circulation, 117, 1045-1054.
    View publication on PubMed
Search for more literature for 3.5.4.16

Application

Application Comment Organism
medicine endothelium-specific GTPCH I overexpression retards the progression of hypertension through preservation of the structure and function of resistance mesenteric arteries, endothelium-specific GTPCH I overexpression abrogates superoxide anion production and preserves endothelial nitric oxide synthase phosphorylation, which results in preserved structural and functional integrity of resistance mesenteric arteries and lowered blood pressure in low-renin hypertension Homo sapiens

Cloned(Commentary)

Cloned (Comment) Organism
expressed in Mus musculus Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens GTPCH I is the rate-limiting enzyme for de novo tetrahydrobiopterin synthesis ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
endothelium
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information GTPCH I is the rate-limiting enzyme for de novo tetrahydrobiopterin synthesis Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
GTP cyclohydrolase I
-
 Homo sapiens
GTPCH I
-
 Homo sapiens