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Literature summary for 3.5.4.16 extracted from

  • Hung, Y.C.; Tsai, P.S.; Huang, C.J.; Yang, S.; Skimming, J.W.; Hsieh, M.C.
    Change in expression of the guanosine triphosphate cyclohydrolase I in LPS-stimulated rats is tissue specific (2004), Acta Anaesthesiol. Taiwan., 42, 23-31.
    View publication on PubMed
Search for more literature for 3.5.4.16

Activating Compound

Activating Compound Comment Organism Structure
additional information lipopolysaccharide application by injection increases enzyme expression in kidney, but not in liver and lung Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
GTP + H2O Rattus norvegicus the enzyme controls the biosynthesis pathway of tetrahydrobiopterin, which is a necessary cofactor for inducible nitric oxide synthase formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate
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 ?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
 male sprague-dawley rats
-

Source Tissue

Source Tissue Comment Organism Textmining
kidney
-
 Rattus norvegicus
-
liver
-
 Rattus norvegicus
-
lung
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
GTP + H2O
-
 Rattus norvegicus formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate
-
 ?
GTP + H2O the enzyme controls the biosynthesis pathway of tetrahydrobiopterin, which is a necessary cofactor for inducible nitric oxide synthase Rattus norvegicus formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate
-
 ?

Synonyms

Synonyms Comment Organism
GTPCH
-
 Rattus norvegicus
guanosine triphosphate cyclohydrolase I
-
 Rattus norvegicus