Cloned (Comment) | Organism |
---|---|
cloned into the yeast expression vector pVT103-U and introduced into yeast strain 971/6a | Arabidopsis thaliana |
cloned into the yeast expression vector pVT103-U and introduced into yeast strain 971/6a | Solanum lycopersicum |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
GTP | substrate inhibition above 0.1 mM | Solanum lycopersicum |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.046 | - |
GTP | pH 8.0, 37°C, recombinant enzyme | Solanum lycopersicum |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytosol | - |
Solanum lycopersicum | 5829 | - |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
50000 | - |
2 * 50000 | Solanum lycopersicum |
91000 | - |
gel filtration | Solanum lycopersicum |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
GTP + H2O | Solanum lycopersicum | the enzyme mediates the first and committing step of the pterin branch of the folate-synthesis pathway | formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate | - |
? | |
GTP + H2O | Arabidopsis thaliana | the enzyme mediates the first and committing step pf the pterin branch of the folate-synthesis pathway | formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate | - |
? | |
GTP + H2O | Arabidopsis thaliana | the enzyme mediates the first and committing step of the pterin branch of the folate-synthesis pathway | formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Arabidopsis thaliana | Q8S3C2 | - |
- |
Solanum lycopersicum | Q8VYU3 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
fruit | GCHI mRNA level is highest in unripe fruit | Solanum lycopersicum | - |
leaf | - |
Arabidopsis thaliana | - |
leaf | - |
Solanum lycopersicum | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
GTP + H2O | - |
Arabidopsis thaliana | formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate | - |
? | |
GTP + H2O | - |
Solanum lycopersicum | formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate | - |
? | |
GTP + H2O | the enzyme mediates the first and committing step of the pterin branch of the folate-synthesis pathway | Solanum lycopersicum | formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate | - |
? | |
GTP + H2O | the enzyme mediates the first and committing step pf the pterin branch of the folate-synthesis pathway | Arabidopsis thaliana | formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate | - |
? | |
GTP + H2O | the enzyme mediates the first and committing step of the pterin branch of the folate-synthesis pathway | Arabidopsis thaliana | formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate | - |
? |
Subunits | Comment | Organism |
---|---|---|
dimer | 2 * 50000 | Solanum lycopersicum |
Synonyms | Comment | Organism |
---|---|---|
GCHI | - |
Arabidopsis thaliana |
GCHI | - |
Solanum lycopersicum |
GTP cyclohydrolase I | - |
Arabidopsis thaliana |
GTP cyclohydrolase I | - |
Solanum lycopersicum |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.173 | - |
GTP | pH 8.0, 37°C, recombinant enzyme | Solanum lycopersicum |