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Literature summary for 3.5.4.16 extracted from

  • Bader, G.; Schiffmann, S.; Herrmann, A.; Fischer, M.; Gutlich, M.; Auerbach, G.; Ploom, T.; Bacher, A.; Huber, R.; Lemm, T.
    Crystal structure of rat GTP cyclohydrolase I feedback regulatory protein, GFRP (2001), J. Mol. Biol., 312, 1051-1057.
    View publication on PubMed
Search for more literature for 3.5.4.16

Crystallization (Commentary)

Crystallization (Comment) Organism
5 mg/ml enzyme subunit GTP cyclohydrolase I feedback regulatory protein, i.e. GFRP, free and complexed with the human catalytic subunit of the enzyme, batch procedure, at 4°C overnight, total reflection X-ray fluorescence spectrometry, structure determination and analysis at 2.6 A resolution, modeling Rattus norvegicus

Inhibitors

Inhibitors Comment Organism Structure
tetrahydrobiopterin the cofactor required for hydroxylation of aromatic amino acids regulates its own synthesis through feedback inhibition of the enzyme mediated by the regulatory subunit called GTP cyclohydrolase I feedback regulatory protein, i.e. GFRP Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
GTP + H2O Rattus norvegicus
-
 dihydroneopterin triphosphate + formate
-
 ?
additional information Rattus norvegicus tetrahydrobiopterin, the cofactor required for hydroxylation of aromatic amino acids, regulates its own synthesis through feedback inhibition of the enzyme mediated by the regulatory subunit called GTP cyclohydrolase I feedback regulatory protein, i.e. GFRP ?
-
 ?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
GTP + H2O
-
 Rattus norvegicus dihydroneopterin triphosphate + formate
-
 ?
additional information tetrahydrobiopterin, the cofactor required for hydroxylation of aromatic amino acids, regulates its own synthesis through feedback inhibition of the enzyme mediated by the regulatory subunit called GTP cyclohydrolase I feedback regulatory protein, i.e. GFRP Rattus norvegicus ?
-
 ?

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
 assay at Rattus norvegicus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.5
-
 assay at Rattus norvegicus