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Literature summary for 3.5.4.16 extracted from
- Purification and characterization of GTP cyclohydrolase I from Streptomyces tubercidicus, a producer of tubercidin (1998), Arch. Pharm. Res., 21, 692-697.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| Ca2+ | - |
Streptomyces tubercidicus |  |
| Co2+ | - |
Streptomyces tubercidicus | |
| CTP | - |
Streptomyces tubercidicus | |
| Cu2+ | - |
Streptomyces tubercidicus | |
| Fe2+ | - |
Streptomyces tubercidicus | |
| GDP | - |
Streptomyces tubercidicus | |
| GMP | - |
Streptomyces tubercidicus | |
| K+ | - |
Streptomyces tubercidicus | |
| Mg2+ | - |
Streptomyces tubercidicus | |
| Mn2+ | - |
Streptomyces tubercidicus | |
| Na+ | - |
Streptomyces tubercidicus | |
| Ni2+ | - |
Streptomyces tubercidicus | |
| UTP | - |
Streptomyces tubercidicus | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.08 | - |
GTP | - |
Streptomyces tubercidicus | |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 58000 | - |
4 * 58000, SDS-PAGE | Streptomyces tubercidicus |
| 230000 | - |
gel filtration | Streptomyces tubercidicus |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Streptomyces tubercidicus | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Streptomyces tubercidicus |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| 9.1 | - |
- |
Streptomyces tubercidicus |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| GTP + H2O | - |
Streptomyces tubercidicus | formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| tetramer | 4 * 58000, SDS-PAGE | Streptomyces tubercidicus |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 40 | 42 | - |
Streptomyces tubercidicus |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7.5 | 8.5 | - |
Streptomyces tubercidicus |
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Release 2023.1 (January 2023)
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