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Literature summary for 3.5.4.16 extracted from
- Purification and characterization of GTP cyclohydrolase I from Drosophila melanogaster (1986), J. Biol. Chem., 261, 1453-1458.
General Stability
| General Stability | Organism |
|---|---|
| bovine serum albumin stabilizes | Drosophila melanogaster |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| ATP | - |
Drosophila melanogaster |  |
| Ca2+ | - |
Drosophila melanogaster | |
| divalent cations | - |
Drosophila melanogaster | |
| GTP | substrate inhibition above 0.2 mM | Drosophila melanogaster | |
| ITP | - |
Drosophila melanogaster | |
| KCl | - |
Drosophila melanogaster | |
| Mg2+ | - |
Drosophila melanogaster | |
| Mn2+ | - |
Drosophila melanogaster | |
| NaCl | - |
Drosophila melanogaster | |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 39000 | - |
x * 39000, SDS-PAGE | Drosophila melanogaster |
| 575000 | - |
gel filtration | Drosophila melanogaster |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Drosophila melanogaster | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Drosophila melanogaster |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| additional information | - |
- |
Drosophila melanogaster |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| GTP + H2O | - |
Drosophila melanogaster | formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| polymer | x * 39000, SDS-PAGE | Drosophila melanogaster |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 60 | - |
- |
Drosophila melanogaster |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7.3 | - |
phosphate buffer: 2 optima, pH 7.3 and 8.0 | Drosophila melanogaster |
| 8 | - |
phosphate buffer: 2 optima, pH 7.3 and 8.0 | Drosophila melanogaster |
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