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Literature summary for 3.5.4.13 extracted from

  • Helt, S.S.; Thymark, M.; Harris, P.; Aagaard, C.; Dietrich, J.; Larsen, S.; Willemoes, M.
    Mechanism of dTTP inhibition of the bifunctional dCTP deaminase:dUTPase encoded by Mycobacterium tuberculosis (2008), J. Mol. Biol., 376, 554-569.
    View publication on PubMed
Search for more literature for 3.5.4.13

Inhibitors

Inhibitors Comment Organism Structure
dTTP the inhibitor has a regukatory function for the bifunctional enzyme, mechanism of regulation by conformational changes, overview Mycobacterium tuberculosis

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
additional information
-
 additional information steady-state kinetic analysis Mycobacterium tuberculosis

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
dCTP + H2O Mycobacterium tuberculosis
-
 dUTP + NH3
-
 ?
dCTP + H2O Mycobacterium tuberculosis H37Rv
-
 dUTP + NH3
-
 ?

Organism

Organism UniProt Comment Textmining
Mycobacterium tuberculosis P9WP17
-
-
Mycobacterium tuberculosis H37Rv P9WP17
-
-

Reaction

Reaction Comment Organism Reaction ID
dCTP + H2O = dUTP + NH3 the mechanism for the deamination of dCTP involves the four residues Ser102, Arg106, Ala115 and Glu129, structure-function relationship of the bifunctional enzyme, overview Mycobacterium tuberculosis
a

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
dCTP + H2O
-
 Mycobacterium tuberculosis dUTP + NH3
-
 ?
dCTP + H2O
-
 Mycobacterium tuberculosis H37Rv dUTP + NH3
-
 ?
additional information the enzyme is a bifunctional dCTP deaminase:dUTPase Mycobacterium tuberculosis ?
-
 ?
additional information the enzyme is a bifunctional dCTP deaminase:dUTPase Mycobacterium tuberculosis H37Rv ?
-
 ?

Synonyms

Synonyms Comment Organism
dCTP deaminase:deoxyuridine triphosphatase
-
 Mycobacterium tuberculosis
dCTP deaminase:dUTPase
-
 Mycobacterium tuberculosis
deoxycytidine triphosphate deaminase
-
 Mycobacterium tuberculosis