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Literature summary for 3.5.4.12 extracted from

  • Niu, M.; Wang, Y.; Wang, C.; Lyu, J.; Wang, Y.; Dong, H.; Long, W.; Wang, D.; Kong, W.; Wang, L.; Guo, X.; Sun, L.; Hu, T.; Zhai, H.; Wang, H.; Wan, J.
    ALR encoding dCMP deaminase is critical for DNA damage repair, cell cycle progression and plant development in rice (2017), J. Exp. Bot., 68, 5773-5786 .
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
expression in Escherichia coli BL21 (DE3) Oryza sativa

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
dCMP + H2O Oryza sativa the enzyme is crucial to the production of dTTP needed for DNA replication and damage repair. It mediates dNTP pool balance required for normal chloroplast development and vegetative growth in plants dUMP + NH3
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?

Organism

Organism UniProt Comment Textmining
Oryza sativa Q5JN09 subsp. japonica
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Purification (Commentary)

Purification (Comment) Organism
-
Oryza sativa

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
dCMP + H2O
-
Oryza sativa dUMP + NH3
-
?
dCMP + H2O the enzyme is crucial to the production of dTTP needed for DNA replication and damage repair. It mediates dNTP pool balance required for normal chloroplast development and vegetative growth in plants Oryza sativa dUMP + NH3
-
?

Synonyms

Synonyms Comment Organism
DCD
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Oryza sativa
deoxycytidine monophosphate deaminase
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Oryza sativa

General Information

General Information Comment Organism
malfunction DELTA(DCD) protein in the alr mutant (albinic leaf and growth retardation) is a loss-of-function protein that lacks binding ability. Deoxycytidine monophosphate deaminase deficiency causes accumulation of DNA damage in the alr mutant, sometimes leading to cell apoptosis. Deoxycytidine monophosphate deaminase deficiency triggers cell cycle checkpoints and arrests cell progression at the G1/S-phase. Decreased cell proliferation and defective chloroplast development in the alr mutant is demonstrated. The expression of nuclear and plastid genome replication genes is down-regulated under decreased dTTP Oryza sativa
metabolism the enzyme is crucial to the production of dTTP needed for DNA replication and damage repair. It mediates dNTP pool balance required for normal chloroplast development and vegetative growth in plants Oryza sativa