Inhibitors | Comment | Organism | Structure |
---|---|---|---|
2',3'-dihydro-2',3'-dideoxy-thymidine monophosphate | - |
Homo sapiens | |
3'-azido-2',3'-dideoxy-thymidine monophosphate | - |
Homo sapiens | |
5-fluoro-dUMP | - |
Homo sapiens | |
beta-D-2',2'-difluorodeoxycytidine | competitive | Homo sapiens | |
beta-L-2',3'-dideoxy-3'-thiacytidine monophosphate | slight inhibition | Homo sapiens | |
beta-L-2',3'-dideoxy-5'-fluoro-3'-thiacytidine monophosphate | - |
Homo sapiens | |
D-beta-2'-fluoro-5-methyl-arabinofuranosyluracil monophosphate | no inhibition by L-beta-2'-fluoro-5-methyl-arabinofuranosyluracil monophosphate | Homo sapiens | |
dUMP | product inhibition | Homo sapiens | |
additional information | inhibitory potency of pyrimidine phosphate analogues, overview | Homo sapiens | |
TMP | - |
Homo sapiens |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.022 | - |
dCMP | pH 7.5 | Homo sapiens |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Mg2+ | - |
Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
dCMP + H2O | Homo sapiens | the enzyme is important in the de novo synthesis of thymidine nucleotides, and may also be involved in the metabolism of anticancer agents | dUMP + NH3 | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Purification (Comment) | Organism |
---|---|
native enzyme 60fold from Hep-G2 cells by adsorption chromatography | Homo sapiens |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
Hep-G2 cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
beta-D-2',2'-difluorodeoxycytidine + H2O | - |
Homo sapiens | beta-D-2',2'-difluorodeoxyuridine + NH3 | - |
? | |
dCMP + H2O | - |
Homo sapiens | dUMP + NH3 | - |
? | |
dCMP + H2O | the enzyme is important in the de novo synthesis of thymidine nucleotides, and may also be involved in the metabolism of anticancer agents | Homo sapiens | dUMP + NH3 | - |
? | |
additional information | substrate specificity with deoxycytidine analogue monophosphates, overview | Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
dCMP deaminase | - |
Homo sapiens |
deoxycytidylate deaminase | - |
Homo sapiens |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.5 | - |
assay at | Homo sapiens |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0046 | - |
TMP | pH 7.5 | Homo sapiens | |
0.0103 | - |
D-beta-2'-fluoro-5-methyl-arabinofuranosyluracil monophosphate | pH 7.5 | Homo sapiens | |
0.0142 | - |
5-fluoro-dUMP | pH 7.5 | Homo sapiens | |
0.0257 | - |
dUMP | pH 7.5 | Homo sapiens | |
0.0367 | - |
3'-azido-2',3'-dideoxy-thymidine monophosphate | pH 7.5 | Homo sapiens | |
0.0394 | - |
2',3'-dihydro-2',3'-dideoxy-thymidine monophosphate | pH 7.5 | Homo sapiens |