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Literature summary for 3.5.4.12 extracted from

  • Nucci, R.; Febbraio, F.; Piccialli, G.; de Napoli, L.; Vaccaro, C.; Rossi, M.; Whitehead, E.P.
    Interaction of the high-affinity inhibitor tetrahydro-dUMP with the allosteric enzyme deoxycytidylate aminohydrolase (1994), Arch. Biochem. Biophys., 310, 49-53.
    View publication on PubMed
Search for more literature for 3.5.4.12

Activating Compound

Activating Compound Comment Organism Structure
3,4,5,6-tetrahydro-2'-dUMP high-affinity inhibitor, rapid, reversible inhibition, kinetics of inhibition. At low substrate or competitor concentrations: activation. Tetrahydro-dUMP activates enzyme at low substrate concentrations Equus asinus
dCTP positive allosteric effector Equus asinus

Application

Application Comment Organism
pharmacology might have applications in cancer chemotherapy. Enzyme may be an inhibitor target for antitumor agents Equus asinus

Inhibitors

Inhibitors Comment Organism Structure
3,4,5,6-tetrahydro-2'-deoxyuridine
-
 Equus asinus
3,4,5,6-tetrahydro-2'-dUMP high-affinity inhibitor, rapid, reversible inhibition, kinetics of inhibition. At low substrate or competitor concentrations: activation. Tetrahydro-dUMP activates enzyme at low substrate concentrations Equus asinus
additional information kinetics of inhibition; mechanism of inhibition Equus asinus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
additional information
-
 additional information kinetics of inhibition Equus asinus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
dCMP + H2O Equus asinus
-
 dUMP + NH3
-
 ?

Organism

Organism UniProt Comment Textmining
Equus asinus
-
 donkey
-

Purification (Commentary)

Purification (Comment) Organism
-
 Equus asinus

Reaction

Reaction Comment Organism Reaction ID
dCMP + H2O = dUMP + NH3 mechanism Equus asinus
a
dCMP + H2O = dUMP + NH3 regulation, allosteric end-product regulation Equus asinus
a
dCMP + H2O = dUMP + NH3 highly regulated allosteric enzyme Equus asinus
a

Source Tissue

Source Tissue Comment Organism Textmining
spleen
-
 Equus asinus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
dCMP + H2O
-
 Equus asinus dUMP + NH3
-
 ?