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Literature summary for 3.5.4.12 extracted from

  • Neale, G.A.M.; Mitchell, A.; Finch, L.R.
    Enzymes of pyrimidine deoxyribonucleotide metabolism in Mycoplasma mycoides subsp. mycoides (1983), J. Bacteriol., 156, 1001-1005.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.5.4.12

Activating Compound

Activating Compound Comment Organism Structure
dCTP activation, absolute requirement for dCTP Mycoplasma mycoides

General Stability

General Stability Organism
highly stable enzyme Mycoplasma mycoides

Inhibitors

Inhibitors Comment Organism Structure
dTTP allosteric inhibitor Mycoplasma mycoides

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
additional information
-
 additional information preliminary kinetic studies and kinetic data Mycoplasma mycoides
0.046
-
 dCMP
-
 Mycoplasma mycoides

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
dCMP + H2O Mycoplasma mycoides enzyme of pyrimidine deoxyribonucleotide metabolism, important for the synthesis of thymidine nucleotides from thymine. Enzyme could provide the major means of dUMP formation dUMP + NH3
-
 ?

Organism

Organism UniProt Comment Textmining
Mycoplasma mycoides
-
 subsp. mycoides
-

Reaction

Reaction Comment Organism Reaction ID
dCMP + H2O = dUMP + NH3 regulation, allosteric end-product regulation Mycoplasma mycoides
a
dCMP + H2O = dUMP + NH3 highly regulated allosteric enzyme Mycoplasma mycoides
a

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
dCMP + H2O
-
 Mycoplasma mycoides dUMP + NH3
-
 ?
dCMP + H2O enzyme of pyrimidine deoxyribonucleotide metabolism, important for the synthesis of thymidine nucleotides from thymine. Enzyme could provide the major means of dUMP formation Mycoplasma mycoides dUMP + NH3
-
 ?

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
 assay at Mycoplasma mycoides

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.8
-
 assay at Mycoplasma mycoides