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Literature summary for 3.5.4.1 extracted from
- Restriction of porcine endogenous retrovirus by porcine APOBEC3 cytidine deaminases (2011), J. Virol., 85, 3842-3857.
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Sus scrofa | - |
pigs express four different A3 mRNAs encoding poA3Z2, poA3Z3, and by read-through transcription and alternatively splicing poA3Z2-Z3 and poA3Z2-Z3 splice variant A (SVA) | - |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| APOBEC3 | - |
Sus scrofa |
General Information
| General Information | Comment | Organism |
|---|---|---|
| physiological function | porcine A3 is tested toward their antiretroviral activity against porcine endogenous retrovirus (PERV) and murine leukemia virus (MuLV) using novel single-round reporter viruses. The porcine A3Z2, A3Z3 and A3Z2-Z3 mRNAs are packaged into PERV particles and inhibit PERV replication in a dose-dependent manner. The antiretroviral effect correlate with editing by the porcine A3s with a trinucleotide preference for 5' TGC for A3Z2 and A3Z2-Z3 and 5' CAC for A3Z3 | Sus scrofa |
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Release 2023.1 (January 2023)
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