Literature summary for 3.5.4.1 extracted from

Kucerova, L.; Matuskova, M.; Hlubinova, K.; Bohovic, R.; Feketeova, L.; Janega, P.; Babal, P.; Poturnajova, M.
Bystander cytotoxicity in human medullary thyroid carcinoma cells mediated by fusion yeast cytosine deaminase and 5-fluorocytosine (2011), Cancer Lett., 311, 101-112.

Search for more literature for 3.5.4.1

Application

Application	Comment	Organism
medicine	efficiency of gene-directed enzyme/prodrug therapy (GDEPT) based on combination of fusion yeast cytosine deaminase (yCD) and 5-fluorocytosine (5FC) on model human medullary thyroid carcinoma (MTC) cell line TT is determined. Significant bystander effect is shown in vitro and 5-fluorocytosine administration results in potent antitumor effect in vivo. In addition high efficiency of cell-mediated GDEPT is shown, when human mesenchymal stromal cells are used as delivery vehicles in direct cocultures in vitro	Saccharomyces cerevisiae

Organism

Organism	UniProt	Comment	Textmining
Saccharomyces cerevisiae	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
5-fluorocytosine + H2O	-	Saccharomyces cerevisiae	5-fluorouracil + NH3	-	?

Synonyms

Synonyms	Comment	Organism
yCD	-	Saccharomyces cerevisiae

Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.

Release 2023.1 (January 2023)