Cloned (Comment) | Organism |
---|---|
expression of the enzyme in Rattus norvegicus, BDIX rats, in induced colorectal adenocarcinoma in a gene therapy approach | Escherichia coli |
Protein Variants | Comment | Organism |
---|---|---|
additional information | expression of the enzyme in Rattus norvegicus, BDIX rats, in induced colorectal adenocarcinoma in a gene therapy approach leads to intratumor chemotherapy using 5-fluorocytosine, which is locally converted to 5-fluorouracil, the treatment results in destruction of the gene-modified tumor, other physiological processes might contribute to the tumor destruction, overview | Escherichia coli |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
cytosine + H2O | Escherichia coli | treatment of BDIX rat colon cancer cells using the cytosine deaminase/5-fluorocytosine suicide system induces apoptosis, modulation of the proteome, and Hsp90beta phosphorylation, mechanism of the anticancer effect, overview | uracil + NH3 | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Escherichia coli | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
5-fluorocytosine + H2O | - |
Escherichia coli | 5-fluorouracil + NH3 | - |
? | |
cytosine + H2O | - |
Escherichia coli | uracil + NH3 | - |
? | |
cytosine + H2O | treatment of BDIX rat colon cancer cells using the cytosine deaminase/5-fluorocytosine suicide system induces apoptosis, modulation of the proteome, and Hsp90beta phosphorylation, mechanism of the anticancer effect, overview | Escherichia coli | uracil + NH3 | - |
? |