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Literature summary for 3.5.4.1 extracted from

  • Shieh, G.S.; Shiau, A.L.; Yo, Y.T.; Lin, P.R.; Chang, C.C.; Tzai, T.S.; Wu, C.L.
    Low-dose etoposide enhances telomerase-dependent adenovirus-mediated cytosine deaminase gene therapy through augmentation of adenoviral infection and transgene expression in a syngeneic bladder tumor model (2006), Cancer Res., 66, 9957-9966.
    View publication on PubMed
Search for more literature for 3.5.4.1

Activating Compound

Activating Compound Comment Organism Structure
additional information low-dose etoposide enhances telomerase-dependent adenovirus-mediated cytosine deaminase gene therapy through augmentation of adenoviral infection and transgene expression in a syngeneic bladder tumor model, overview Escherichia coli

Application

Application Comment Organism
medicine the enzyme is useful in gene therapy for treatment of cancer, bladder tumor model, overview Escherichia coli

Cloned(Commentary)

Cloned (Comment) Organism
expression of the recombinant fusion gene from adenoviral vector under control of the human telomerase reverse transcriptase promoter in murine syngeneic MBT-2 bladder tumor cells, overview Escherichia coli

Protein Variants

Protein Variants Comment Organism
additional information construction of a fusion gene in an adenoviral vector comprising human telomerase reverse transcriptase promoter, and cytosine deaminase from Escherichia coli Escherichia coli

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
cytosine + H2O Escherichia coli
-
 uracil + NH3
-
 ?
additional information Escherichia coli low-dose etoposide enhances telomerase-dependent adenovirus-mediated cytosine deaminase gene therapy through augmentation of adenoviral infection and transgene expression in a syngeneic bladder tumor model, overview ?
-
 ?

Organism

Organism UniProt Comment Textmining
Escherichia coli
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
5-fluorocytosine + H2O
-
 Escherichia coli 5-fluorouracil + NH3
-
 ?
cytosine + H2O
-
 Escherichia coli uracil + NH3
-
 ?
additional information low-dose etoposide enhances telomerase-dependent adenovirus-mediated cytosine deaminase gene therapy through augmentation of adenoviral infection and transgene expression in a syngeneic bladder tumor model, overview Escherichia coli ?
-
 ?