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Literature summary for 3.5.4.1 extracted from

  • Khatri, A.; Zhang, B.; Doherty, E.; Chapman, J.; Ow, K.; Pwint, H.; Martiniello-Wilks, R.; Russell, P.J.
    Combination of cytosine deaminase with uracil phosphoribosyl transferase leads to local and distant bystander effects against RM1 prostate cancer in mice (2006), J. Gene Med., 8, 1086-1096.
    View publication on PubMed
Search for more literature for 3.5.4.1

Protein Variants

Protein Variants Comment Organism
additional information construction of a fusion gene using cytosine deaminase in combination with uracil phosphoribosyl transferase, the product of the suicide gene, CDUPRT, converts the prodrug, 5-fluorocytosine, into 5-fluorouracil and other cytotoxic metabolites that kill both CDUPRT-expressing and surrounding cells, via a bystander effect, in pseudo-metastates in mouse tissues, tissue-specifix effects, overview Escherichia coli

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
5-fluorocytosine + H2O Escherichia coli recombinant enzyme, combination of cytosine deaminase with uracil phosphoribosyl transferase leads to local and distant bystander effects against RM1 prostate cancer in mice in gene-directed enzyme prodrug therapy, overview 5-fluorouracil + NH3
-
 ?
cytosine + H2O Escherichia coli
-
 uracil + NH3
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 ?

Organism

Organism UniProt Comment Textmining
Escherichia coli
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-
-

Source Tissue

Source Tissue Comment Organism Textmining

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
5-fluorocytosine + H2O recombinant enzyme, combination of cytosine deaminase with uracil phosphoribosyl transferase leads to local and distant bystander effects against RM1 prostate cancer in mice in gene-directed enzyme prodrug therapy, overview Escherichia coli 5-fluorouracil + NH3
-
 ?
5-fluorocytosine + H2O activation of the prodrug Escherichia coli 5-fluorouracil + NH3
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 ?
cytosine + H2O
-
 Escherichia coli uracil + NH3
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 ?