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Literature summary for 3.5.4.1 extracted from

  • Hwang, K.; Cho, W.; Yoo, J.; Yun, H.; Kim, S.; Im, D.
    Adenovirus-mediated interleukin-12 gene transfer combined with cytosine deaminase followed by 5-fluorocytosine treatment exerts potent antitumor activity in Renca tumor-bearing mice (2005), BMC Cancer, 5, 51.
    View publication on PubMedView publication on EuropePMC

Application

Application Comment Organism
medicine inhibition of tumor growth in mice treated with gene transfer of interleukin IL-12 plus enzyme/5-fluorcytosine is significantly greater than in mice treated with enzyme or IL-12 alone. Combined gene transfer increases splenic natural killer cell activity and interferon-gamma production by slenocytes and increases tumor growth inhibition and mean animal survival time Mus musculus

Organism

Organism UniProt Comment Textmining
Mus musculus
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renal cell carcinoma tumor-bearing mice
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