Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
HMEC cell | - |
Homo sapiens | - |
Synonyms | Comment | Organism |
---|---|---|
arginine deiminase | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
malfunction | ADI modulates the angiogenic activity of endothelial tip cells. By arginine depletion, ADI disturbs actin filament in endothelial tip cells, causing disordered migratory direction and decreased migration ability | Homo sapiens |
physiological function | ADI induces excessive synthesis of reactive oxygen species, and activates caspase 8-, but not caspase 9-, dependent apoptosis in endothelial cells | Homo sapiens |