Literature summary for 3.5.3.6 extracted from

Smith, D.W.; Ganaway, R.L.; Fahrney, D.E.
Arginine deiminase from Mycoplasma arthritidis. Structure-activity relationships among substrates and competitive inhibitors (1978), J. Biol. Chem., 253, 6016-6020.

Search for more literature for 3.5.3.6

Inhibitors

Inhibitors	Comment	Organism	Structure
agmatine	-	Mycoplasma arthritidis
aminoguanidine	-	Mycoplasma arthritidis
arcaine	-	Mycoplasma arthritidis
Ethylguanidine	-	Mycoplasma arthritidis
formylguanidine	-	Mycoplasma arthritidis
guanidine	-	Mycoplasma arthritidis
L-alpha-aminobutyrate	-	Mycoplasma arthritidis
L-homoarginine	-	Mycoplasma arthritidis
Lys	-	Mycoplasma arthritidis
methylguanidine	-	Mycoplasma arthritidis
nitroguanidine	-	Mycoplasma arthritidis

KM Value [mM]

KM Value [mM]	KM Value Maximum [mM]	Substrate	Comment	Organism	Structure
0.004	-	L-Arg	-	Mycoplasma arthritidis
0.044	-	L-canavanine	-	Mycoplasma arthritidis
1.2	-	Nalpha-methyl-L-Arg	-	Mycoplasma arthritidis
4.7	-	L-homoarginine	-	Mycoplasma arthritidis
10	-	D-Arg	-	Mycoplasma arthritidis
11	-	guanidine	-	Mycoplasma arthritidis
16	-	L-argininic acid	-	Mycoplasma arthritidis

Organism

Organism	UniProt	Comment	Textmining
Mycoplasma arthritidis	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
D-Arg + H2O	0.38% of the activity with L-Arg	Mycoplasma arthritidis	D-citrulline + NH3	-	?
guanidine + H2O	-	Mycoplasma arthritidis	urea + NH3	-	?
L-Arg + H2O	-	Mycoplasma arthritidis	L-citrulline + NH3	-	ir
L-argininic acid + H2O	0.032% of the activity with L-Arg	Mycoplasma arthritidis	(2S)-5-[(aminocarbonyl)amino]-2-hydroxypentanoic acid + NH3	-	?
L-canavanine + H2O	2.3% of the activity with L-Arg	Mycoplasma arthritidis	(2S)-2-amino-4-[[(aminocarbonyl)amino]oxy]butanoic acid + NH3	-	?
L-homoarginine + H2O	0.05% of the activity with L-Arg	Mycoplasma arthritidis	(2S)-2-amino-6-[(aminocarbonyl)amino]hexanoic acid + NH3	-	?
Nalpha-methyl-L-Arg + H2O	0.75% of the activity with L-Arg	Mycoplasma arthritidis	Nalpha-methyl-L-citrulline + NH3	-	?

Turnover Number [1/s]

Turnover Number Minimum [1/s]	Turnover Number Maximum [1/s]	Substrate	Comment	Organism	Structure
additional information	-	additional information	-	Mycoplasma arthritidis
29	-	L-Arg	-	Mycoplasma arthritidis

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Release 2023.1 (January 2023)