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Literature summary for 3.5.3.24 extracted from
- N1-aminopropylagmatine, a new polyamine produced as a key intermediate in polyamine biosynthesis of an extreme thermophile, Thermus thermophilus (2005), J. Biol. Chem., 280, 30073-30082.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| overexpression in Escherichia coli | Thermus thermophilus |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 32500 | - |
x * 32500, SDS-PAGE | Thermus thermophilus |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| N1-aminopropylagmatine + H2O | Thermus thermophilus | the enzyme is involved in biosynthesis of spermidine. The conversion of N1-aminopropylagmatine to spermidine is essential for production of long and branched polyamines in Thermus thermophilus | spermidine + urea | - |
? |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Thermus thermophilus | Q5SJ85 | - |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Thermus thermophilus |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| N1-aminopropylagmatine + H2O | the enzyme is involved in biosynthesis of spermidine. The conversion of N1-aminopropylagmatine to spermidine is essential for production of long and branched polyamines in Thermus thermophilus | Thermus thermophilus | spermidine + urea | - |
? | |
| N1-aminopropylagmatine + H2O | the enzyme cannot use agmatine as substrate | Thermus thermophilus | spermidine + urea | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| ? | x * 32500, SDS-PAGE | Thermus thermophilus |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 65 | - |
assay at | Thermus thermophilus |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7.4 | - |
assay at | Thermus thermophilus |
General Information
| General Information | Comment | Organism |
|---|---|---|
| malfunction | a disruption mutant accumulates N1-aminopropylagmatine | Thermus thermophilus |
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Release 2023.1 (January 2023)
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