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Literature summary for 3.5.3.18 extracted from
- Endothelial dimethylarginine dimethylaminohydrolase 1 is an important regulator of angiogenesis but does not regulate vascular reactivity or hemodynamic homeostasis (2015), Circulation, 131, 2217-2225 .
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Mus musculus | Q9CWS0 | isoform Ddah1 | - |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| DDAH1 | - |
Mus musculus |
General Information
| General Information | Comment | Organism |
|---|---|---|
| physiological function | in mice specifically lacking Ddah1 expression in endothelial cells, plasma asymmetrical dimethylarginine level is unchanged, and cultured aortas release amounts of asymmetrical dimethylarginine to similar to controls. Vasoreactivity ex vivo and hemodynamics in vivo are unaltered in endothelial DDAH1 mutant mice, while angiogenic responses both ex vivo and in vivo are significantly impaired | Mus musculus |
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Release 2023.1 (January 2023)
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