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Literature summary for 3.5.3.18 extracted from

  • Kotthaus, J.; Schade, D.; Kotthaus, J.; Clement, B.
    Designing modulators of dimethylarginine dimethylaminohydrolase (DDAH): a focus on selectivity over arginase (2012), J. Enzyme Inhib. Med. Chem., 27, 24-28.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
human DDAH-1 is expressed in Escherichia coli BL21 Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
(2S)-2-amino-5-(ethanimidoylamino)pentanoic acid
-
Homo sapiens
(2S)-2-amino-5-(N'-butylcarbamimidamido)pentanoic acid
-
Homo sapiens
(2S)-2-amino-5-(pent-4-enimidoylamino)pentanoic acid
-
Homo sapiens
(2S)-2-amino-5-(pentanimidoylamino)pentanoic acid
-
Homo sapiens
(2S)-2-amino-5-(propanimidoylamino)pentanoic acid
-
Homo sapiens
(2S)-2-amino-5-[(4E)-hex-4-enimidoylamino]pentanoic acid
-
Homo sapiens
(2S)-2-amino-5-[N'-(3,3,3-trifluoropropyl)carbamimidamido]pentanoic acid
-
Homo sapiens
(2S)-2-amino-5-[N'-(3-methoxypropyl)carbamimidamido]pentanoic acid
-
Homo sapiens
(2S)-2-amino-5-[N'-(4-amino-4-oxobutyl)carbamimidamido]pentanoic acid
-
Homo sapiens
(2S)-2-amino-5-[N'-(but-3-en-1-yl)carbamimidamido]pentanoic acid
-
Homo sapiens
(2S)-2-amino-5-[N'-(but-3-yn-1-yl)carbamimidamido]pentanoic acid
-
Homo sapiens
(2S)-2-amino-5-[N'-(nitromethyl)carbamimidamido]pentanoic acid
-
Homo sapiens
(2S)-2-amino-5-[N'-(pent-4-en-1-yl)carbamimidamido]pentanoic acid
-
Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.133
-
N,N-dimethyl-L-arginine pH 7.4, 37°C Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Purification (Commentary)

Purification (Comment) Organism
using Ni-NTA-agarose Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
N,N-dimethyl-L-arginine + H2O
-
Homo sapiens dimethylamine + L-citrulline
-
?

Synonyms

Synonyms Comment Organism
dimethylarginine dimethylaminohydrolase
-
Homo sapiens
hDDAH-1
-
Homo sapiens

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
assay at Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.4
-
assay at Homo sapiens

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.002
-
(2S)-2-amino-5-(pent-4-enimidoylamino)pentanoic acid pH 7.4, 37°C Homo sapiens
0.013
-
(2S)-2-amino-5-[N'-(3-methoxypropyl)carbamimidamido]pentanoic acid pH 7.4, 37°C, inhibitor is selective over NOS and over arginase Homo sapiens
0.017
-
(2S)-2-amino-5-[N'-(but-3-yn-1-yl)carbamimidamido]pentanoic acid pH 7.4, 37°C Homo sapiens
0.032
-
(2S)-2-amino-5-(pentanimidoylamino)pentanoic acid pH 7.4, 37°C Homo sapiens
0.036
-
(2S)-2-amino-5-[(4E)-hex-4-enimidoylamino]pentanoic acid pH 7.4, 37°C Homo sapiens
0.057
-
(2S)-2-amino-5-[N'-(pent-4-en-1-yl)carbamimidamido]pentanoic acid pH 7.4, 37°C Homo sapiens
0.058
-
(2S)-2-amino-5-[N'-(but-3-en-1-yl)carbamimidamido]pentanoic acid pH 7.4, 37°C Homo sapiens
0.09
-
(2S)-2-amino-5-(N'-butylcarbamimidamido)pentanoic acid pH 7.4, 37°C Homo sapiens
0.145
-
(2S)-2-amino-5-(propanimidoylamino)pentanoic acid pH 7.4, 37°C Homo sapiens
0.606
-
(2S)-2-amino-5-[N'-(3,3,3-trifluoropropyl)carbamimidamido]pentanoic acid pH 7.4, 37°C Homo sapiens
0.764
-
(2S)-2-amino-5-[N'-(4-amino-4-oxobutyl)carbamimidamido]pentanoic acid pH 7.4, 37°C Homo sapiens
1.155
-
(2S)-2-amino-5-(ethanimidoylamino)pentanoic acid pH 7.4, 37°C Homo sapiens
1.968
-
(2S)-2-amino-5-[N'-(nitromethyl)carbamimidamido]pentanoic acid pH 7.4, 37°C Homo sapiens