Literature summary for 3.5.3.18 extracted from

Pope, A.J.; Karrupiah, K.; Kearns, P.N.; Xia, Y.; Cardounel, A.J.
Role of dimethylarginine dimethylaminohydrolases in the regulation of endothelial nitric oxide production (2009), J. Biol. Chem., 284, 35338-35347.

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Organism

Organism	UniProt	Comment	Textmining
Bos taurus	P56965	isoform DDAH-1	-
Bos taurus	Q3SX44	isoform DDAH-2	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
endothelial cell	aortic endothelial cell	Bos taurus	-

Synonyms

Synonyms	Comment	Organism
DDAH-2	-	Bos taurus

General Information

General Information	Comment	Organism
physiological function	overexpression of DDAH-1 increases endothelial nitric oxide by 24%. Small interfering RNA-mediated down-regulation of DDAH-1 reduces nitric oxide bioavailability by 27%. The reduction in nitric oxide production following DDAH-1 gene silencing is associated with a 48% reduction in L-Arg/asymmetric dimethylarginine and is partially restored with L-Arg supplementation	Bos taurus
physiological function	overexpression of DDAH-2 increases endothelial nitric oxide by 18%. Small interfering RNA-mediated down-regulation of DDAH-2 reduces nitric oxide bioavailability by 57%. L-Arg and asymmetric dimethylarginine are unchanged in the DDAH-2-silenced cells, and L-Arg supplementation has no effect on nitric oxide	Bos taurus

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Release 2023.1 (January 2023)