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Literature summary for 3.5.3.18 extracted from
- Nitric oxide upregulates dimethylarginine dimethylaminohydrolase-2 via cyclic GMP induction in endothelial cells (2008), Hypertension, 52, 903-909.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| additional information | increase of DDAH-2 mRNA and protein level induced by SNAP, NOR, 8-bromo-cGMP or CNP | Rattus norvegicus | |
| SNAP | increase of DDAH-2 mRNA and protein level, time and concentration dependent | Homo sapiens |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| additional information | decrease of DDAH-2 mRNA level induced by 10% serum, ionomycin or endothelial growth factors | Rattus norvegicus | |
| N(G)-nitro-L-arginine methyl ester | reduced DDAH-2 mRNA level | Mus musculus |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
| Mus musculus | - |
C57BL/6J, after tretmend with an NOS inhibitor used as a model of chronic nitric oxide expression | - |
| Rattus norvegicus | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| aorta | - |
Mus musculus | - |
| aortic endothelial cell | - |
Rattus norvegicus | - |
| heart | - |
Mus musculus | - |
| retinal cell line | endothelial cells | Homo sapiens | - |
| umbilical vein endothelial cell | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| N-monomethyl-L-arginine + H2O | - |
Mus musculus | L-citrulline + methylamine | - |
? | |
| N-monomethyl-L-arginine + H2O | - |
Homo sapiens | L-citrulline + methylamine | - |
? | |
| N-monomethyl-L-arginine + H2O | - |
Rattus norvegicus | L-citrulline + methylamine | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| DDAH | - |
Mus musculus |
| DDAH | - |
Homo sapiens |
| DDAH | - |
Rattus norvegicus |
| DDAH-2 | - |
Mus musculus |
| DDAH-2 | - |
Homo sapiens |
| DDAH-2 | - |
Rattus norvegicus |
| dimethylarginine dimethylaminohydrolase | - |
Mus musculus |
| dimethylarginine dimethylaminohydrolase | - |
Homo sapiens |
| dimethylarginine dimethylaminohydrolase | - |
Rattus norvegicus |
| dimethylarginine dimethylaminohydrolase-2 | - |
Mus musculus |
| dimethylarginine dimethylaminohydrolase-2 | - |
Homo sapiens |
| dimethylarginine dimethylaminohydrolase-2 | - |
Rattus norvegicus |
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Release 2023.1 (January 2023)
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