Cloned (Comment) | Organism |
---|---|
expression in Escherichia coli BL21 | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
N5-(but-3-en-1-ylcarbamimidoyl)-L-ornithine | 1 mM, 71% inhibition | Homo sapiens | |
N5-(nitrocarbamimidoyl)-L-ornithine | 1 mM, 6% inhibition | Homo sapiens | |
N5-(prop-2-en-1-ylcarbamimidoyl)-L-ornithine | 1 mM, 70% inhibition | Homo sapiens | |
N5-(prop-2-yn-1-ylcarbamimidoyl)-L-ornithine | 1 mM, 83% inhibition | Homo sapiens | |
N5-(propylcarbamimidoyl)-L-ornithine | 1 mM, 60% inhibition | Homo sapiens | |
N5-but-3-enimidoyl-L-ornithine | 1 mM, 97% inhibition | Homo sapiens | |
N5-butanimidoyl-L-ornithine | 1 mM, 78% inhibition | Homo sapiens | |
N5-ethanimidoyl-L-ornithine | 1 mM, 24% inhibition | Homo sapiens | |
N5-propanimidoyl-L-ornithine | 1 mM, 65% inhibition | Homo sapiens | |
N5-[(2,2,2-trifluoroethyl)carbamimidoyl]-L-ornithine | 1 mM, 41% inhibition | Homo sapiens | |
N5-[(2-methoxyethyl)carbamimidoyl]-L-ornithine | 1 mM, 89% inhibition | Homo sapiens | |
N5-[(3-amino-3-oxopropyl)carbamimidoyl]-L-ornithine | 1 mM, 43% inhibition | Homo sapiens | |
N5-[(3E)-pent-3-enimidoyl]-L-ornithine | 1 mM, 73% inhibition | Homo sapiens | |
N5-[imino(morpholin-4-yl)methyl]-L-ornithine | 1 mM, 23% inhibition | Homo sapiens |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.106 | - |
N5-(methylcarbamimidoyl)-L-ornithine | 37°C, 30 min, pH 7.4 | Homo sapiens | |
0.13 | - |
N5-(methoxycarbamimidoyl)-L-ornithine | 37°C, 30 min, pH 7.4 | Homo sapiens | |
0.161 | - |
N5-[2,5-dihydro-1H-pyrrol-1-yl(imino)methyl]-L-ornithine | 37°C, 30 min, pH 7.4 | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
N5-(methoxycarbamimidoyl)-L-ornithine + H2O | assay at 37°C, 30 min, pH 7.4 | Homo sapiens | L-citrulline + ? | - |
? | |
N5-(methylcarbamimidoyl)-L-ornithine + H2O | assay at 37°C, 30 min, pH 7.4 | Homo sapiens | L-citrulline + ? | - |
? | |
N5-[2,5-dihydro-1H-pyrrol-1-yl(imino)methyl]-L-ornithine + H2O | assay at 37°C, 30 min, pH 7.4 | Homo sapiens | L-citrulline + ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
human DDAH-1 | - |
Homo sapiens |
human dimethylarginine dimethylaminohydrolase-1 | - |
Homo sapiens |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Homo sapiens |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.4 | - |
assay at | Homo sapiens |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.002 | - |
N5-but-3-enimidoyl-L-ornithine | - |
Homo sapiens | |
0.013 | - |
N5-[(2-methoxyethyl)carbamimidoyl]-L-ornithine | - |
Homo sapiens | |
0.017 | - |
N5-(prop-2-yn-1-ylcarbamimidoyl)-L-ornithine | - |
Homo sapiens | |
0.032 | - |
N5-butanimidoyl-L-ornithine | - |
Homo sapiens | |
0.036 | - |
N5-[(3E)-pent-3-enimidoyl]-L-ornithine | - |
Homo sapiens | |
0.057 | - |
N5-(but-3-en-1-ylcarbamimidoyl)-L-ornithine | - |
Homo sapiens | |
0.058 | - |
N5-(prop-2-en-1-ylcarbamimidoyl)-L-ornithine | - |
Homo sapiens | |
0.09 | - |
N5-(propylcarbamimidoyl)-L-ornithine | - |
Homo sapiens | |
0.145 | - |
N5-propanimidoyl-L-ornithine | - |
Homo sapiens |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.013 | - |
- |
Homo sapiens | N5-but-3-enimidoyl-L-ornithine | |
0.029 | - |
- |
Homo sapiens | N5-[(2-methoxyethyl)carbamimidoyl]-L-ornithine | |
0.055 | - |
- |
Homo sapiens | N5-(prop-2-yn-1-ylcarbamimidoyl)-L-ornithine | |
0.07 | - |
- |
Homo sapiens | N5-butanimidoyl-L-ornithine | |
0.079 | - |
- |
Homo sapiens | N5-[(3E)-pent-3-enimidoyl]-L-ornithine | |
0.189 | - |
- |
Homo sapiens | N5-(but-3-en-1-ylcarbamimidoyl)-L-ornithine | |
0.207 | - |
- |
Homo sapiens | N5-(prop-2-en-1-ylcarbamimidoyl)-L-ornithine | |
0.283 | - |
- |
Homo sapiens | N5-(propylcarbamimidoyl)-L-ornithine | |
0.3 | - |
- |
Homo sapiens | N5-propanimidoyl-L-ornithine |