Literature summary for 3.5.3.18 extracted from

Dayal, S.; Rodionov, R.N.; Arning, E.; Bottiglieri, T.; Kimoto, M.; Murry, D.J.; Cooke, J.P.; Faraci, F.M.; Lentz, S.R.
Tissue-specific downregulation of dimethylarginine dimethylaminohydrolase in hyperhomocysteinemia (2008), Am. J. Physiol. Heart Circ. Physiol., 295, H816-H825.

Search for more literature for 3.5.3.18

Inhibitors

Inhibitors	Comment	Organism	Structure
additional information	tissue-specific decrease of levels of Ddah1 and Ddah2 RNA after feeding a high-methionine/low-folate diet for 5 to 11 month	Mus musculus

Organism

Organism	UniProt	Comment	Textmining
Mus musculus	-	heterozygous for cystathionine beta-synthase and wild-type	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
aorta	-	Mus musculus	-
brain	-	Mus musculus	-
carotid artery	-	Mus musculus	-
endothelial cell line	MS-1	Mus musculus	-
kidney	-	Mus musculus	-
liver	-	Mus musculus	-
lung	-	Mus musculus	-
pancreatic islet	-	Mus musculus	-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg]	Specific Activity Maximum [µmol/min/mg]	Comment	Organism
0.9	-	mice fed the high-methionine/low folate diet, heterozygous cystathionine beta-synthase	Mus musculus
1.1	-	mice fed the high-methionine/low folate diet, homozygous cystathionine beta-synthase	Mus musculus
1.6	-	mice fed the control diet	Mus musculus

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
N,N-dimethyl-L-arginine + H2O	37°C, 2 h, pH 6.0	Mus musculus	dimethylamine + L-citrulline	-	?

Synonyms

Synonyms	Comment	Organism
DDAH	two seperate DDAH-proteins: Ddah1 and Ddah2	Mus musculus
dimethylarginine dimethylaminohydrolase	-	Mus musculus

Temperature Optimum [°C]

Temperature Optimum [°C]	Temperature Optimum Maximum [°C]	Comment	Organism
37	-	assay at	Mus musculus

pH Optimum

pH Optimum Minimum	pH Optimum Maximum	Comment	Organism
6.9	-	assay at	Mus musculus

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Release 2023.1 (January 2023)