Literature summary for 3.5.3.18 extracted from

Wang, J.; Sim, A.S.; Wang, X.L.; Wilcken, D.E.
L-arginine regulates asymmetric dimethylarginine metabolism by inhibiting dimethylarginine dimethylaminohydrolase activity in hepatic (HepG2) cells (2006), Cell. Mol. Life Sci., 63, 2838-2846.

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Inhibitors

Inhibitors	Comment	Organism	Structure
D-arginine	0.1 mM D-arginine reduces DDAH activity to 24.7%	Homo sapiens
L-arginine	0.1 mM L-arginine competitively inhibits DDAH enzyme activity to 5.6%	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
Hep-G2 cell	-	Homo sapiens	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
NG,NG-dimethyl-L-arginine + H2O	-	Homo sapiens	dimethylamine + L-citrulline	-	?

Synonyms

Synonyms	Comment	Organism
DDAH	-	Homo sapiens
dimethylarginine dimethylaminohydrolase	-	Homo sapiens

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Release 2023.1 (January 2023)