Inhibitors | Comment | Organism | Structure |
---|---|---|---|
additional information | 1 mM tosyl phenylalanyl chloromethyl ketone and 0.043 mM leupeptin do not inhibit enzyme activity | Porphyromonas gingivalis |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cell surface | 90% of enzyme activity is cell surface associated | Porphyromonas gingivalis | 9986 | - |
cytoplasm | 10% of enzyme activity is cytoplasn associated | Porphyromonas gingivalis | 5737 | - |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Porphyromonas gingivalis | - |
- |
- |
Porphyromonas gingivalis W50 | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
agmatine + H2O | 5.4% activity compared to L-arginine | Porphyromonas gingivalis | ? + NH3 | - |
? | |
fibrin L-arginine + H2O | - |
Porphyromonas gingivalis | fibrin L-citrulline + NH3 | - |
? | |
fibrin L-arginine + H2O | - |
Porphyromonas gingivalis W50 | fibrin L-citrulline + NH3 | - |
? | |
Gly-Gly-L-Arg + H2O | 88% activity compared to Nalpha-benzoyl-L-arginine ethyl ester | Porphyromonas gingivalis | Gly-Gly-L-Cit + NH3 | - |
? | |
Gly-Gly-L-Arg + H2O | 88% activity compared to Nalpha-benzoyl-L-arginine ethyl ester | Porphyromonas gingivalis W50 | Gly-Gly-L-Cit + NH3 | - |
? | |
Gly-L-Arg + H2O | 130% activity compared to Nalpha-benzoyl-L-arginine ethyl ester | Porphyromonas gingivalis | Gly-L-Cit + NH3 | - |
? | |
Gly-L-Arg + H2O | 130% activity compared to Nalpha-benzoyl-L-arginine ethyl ester | Porphyromonas gingivalis W50 | Gly-L-Cit + NH3 | - |
? | |
human vimentin L-arginine + H2O | - |
Porphyromonas gingivalis | human vimentin L-citrulline + NH3 | - |
? | |
L-Arg-Gly + H2O | 75% activity compared to Nalpha-benzoyl-L-arginine ethyl ester | Porphyromonas gingivalis | L-Cit-Gly + NH3 | - |
? | |
L-Arg-Gly-Gly + H2O | 66% activity compared to Nalpha-benzoyl-L-arginine ethyl ester | Porphyromonas gingivalis | L-Cit-Gly-Gly + NH3 | - |
? | |
L-arginine + H2O | 28% activity compared to Nalpha-benzoyl-L-arginine ethyl ester | Porphyromonas gingivalis | L-citrulline + NH3 | - |
? | |
L-arginine + H2O | 28% activity compared to Nalpha-benzoyl-L-arginine ethyl ester | Porphyromonas gingivalis W50 | L-citrulline + NH3 | - |
? | |
L-canavanine + H2O | 0.3% activity compared to L-arginine | Porphyromonas gingivalis | ? + NH3 | - |
? | |
L-homoarginine + H2O | 0.3% activity compared to L-arginine | Porphyromonas gingivalis | ? + NH3 | - |
? | |
L-Leu-Trp-Met-Arg + H2O | 45% activity compared to Nalpha-benzoyl-L-arginine ethyl ester | Porphyromonas gingivalis | L-Leu-Trp-Met-Cit + NH3 | - |
? | |
L-Met-Arg-Phe + H2O | the substrate shows fastest rate of citrullination with 158% activity compared to Nalpha-benzoyl-L-arginine ethyl ester | Porphyromonas gingivalis | L-Met-Cit-Phe + NH3 | - |
? | |
L-octopine + H2O | 16.7% activity compared to L-arginine | Porphyromonas gingivalis | ? + NH3 | - |
? | |
Nalpha-benzoyl-L-arginine ethyl ester + H2O | 100% activity | Porphyromonas gingivalis | Nalpha-benzoyl-L-citrulline ethyl ester + NH3 | - |
? | |
Nalpha-benzoyl-L-arginine ethyl ester + H2O | 100% activity | Porphyromonas gingivalis W50 | Nalpha-benzoyl-L-citrulline ethyl ester + NH3 | - |
? | |
yeast enolase L-arginine + H2O | - |
Porphyromonas gingivalis | yeast enolase L-citrulline + NH3 | - |
? |
Synonyms | Comment | Organism |
---|---|---|
PAD | - |
Porphyromonas gingivalis |
peptidylarginine deiminase | - |
Porphyromonas gingivalis |
Temperature Stability Minimum [°C] | Temperature Stability Maximum [°C] | Comment | Organism |
---|---|---|---|
60 | - |
enzyme activity decreases by 13% following exposure of cells to 60°C for 10 min | Porphyromonas gingivalis |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.5 | 8 | - |
Porphyromonas gingivalis |
General Information | Comment | Organism |
---|---|---|
physiological function | enzyme's presence in inflamed tissue may promote autoimmune reactions by creation of altered host epitopes | Porphyromonas gingivalis |