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Literature summary for 3.5.3.15 extracted from

  • Jang, B.; Jeon, Y.C.; Choi, J.K.; Park, M.; Kim, J.I.; Ishigami, A.; Maruyama, N.; Carp, R.I.; Kim, Y.S.; Choi, E.K.
    Peptidylarginine deiminase modulates the physiological roles of enolase via citrullination: links between altered multifunction of enolase and neurodegenerative diseases (2012), Biochem. J., 445, 183-192.
    View publication on PubMed
Search for more literature for 3.5.3.15

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Oryctolagus cuniculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
 Homo sapiens
-
muscle
-
 Oryctolagus cuniculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
alpha-enolase + H2O
-
 Oryctolagus cuniculus [alpha-enolase]-L-citrulline + NH3
-
 ?
neuron-specific-enolase1 + H2O
-
 Oryctolagus cuniculus [neuron-specific]-enolase1 L-citrulline + NH3
-
 ?

Synonyms

Synonyms Comment Organism
PAD
-
 Homo sapiens
PAD
-
 Oryctolagus cuniculus

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
 assay at Oryctolagus cuniculus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.2
-
 assay at Oryctolagus cuniculus

General Information

General Information Comment Organism
physiological function PAD negatively regulates enolase activity via citrullination and enolase activity is more inactive in patients with with sporadic Creutzfeldt-Jakob disease and Alzheimer's disease than in controls Homo sapiens
physiological function PAD negatively regulates enolase activity via citrullination. Thus, PAD-mediated citrullination regulates the diverse physiological activities of enolase Oryctolagus cuniculus