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Literature summary for 3.5.3.15 extracted from

  • Cherrington, B.D.; Morency, E.; Struble, A.M.; Coonrod, S.A.; Wakshlag, J.J.
    Potential role for peptidylarginine deiminase 2 (PAD2) in citrullination of canine mammary epithelial cell histones (2010), PLoS ONE, 5, e11768.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.5.3.15

Localization

Localization Comment Organism GeneOntology No. Textmining
cytoplasm
-
 Canis lupus familiaris 5737
-
nucleus
-
 Canis lupus familiaris 5634
-

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
75000
-
 active enzyme, SDS-PAGE Canis lupus familiaris

Organism

Organism UniProt Comment Textmining
Canis lupus familiaris
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
mammary epithelium mammary alveolar luminal epithelial cell Canis lupus familiaris
-
mammary gland
-
 Canis lupus familiaris
-
mammary gland tumor cell line CMT-25 cell Canis lupus familiaris
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
histone H3 L-Arg + H2O citrullination activity is limited to diestrus with histone H3 Canis lupus familiaris histone H3 L-citrulline + NH3
-
 ?

Synonyms

Synonyms Comment Organism
PAD2
-
 Canis lupus familiaris
peptidylarginine deiminase 2
-
 Canis lupus familiaris

Expression

Organism Comment Expression
Canis lupus familiaris PAD2 expression is low in anestrus down
Canis lupus familiaris estrogen or progesterone do not upregulate PAD2 transcription and translation additional information
Canis lupus familiaris epidermal growth factor upregulates PAD2 transcription and translation. PAD2 expression varies across the estrous cycle, with expression initiating during mammary gland proliferation in estrus/early diestrus and increasing through lactation during diestrus. PAD2 mRNA and protein levels are highest in alveolar unit epithelium during late diestrus up

General Information

General Information Comment Organism
physiological function PAD2 plays a regulatory role in the expression of lactation related genes via histone citrullination during diestrus Canis lupus familiaris