Literature summary for 3.5.3.15 extracted from

Touz, M.C.; Ropolo, A.S.; Rivero, M.R.; Vranych, C.V.; Conrad, J.T.; Svard, S.G.; Nash, T.E.
Arginine deiminase has multiple regulatory roles in the biology of Giardia lamblia (2008), J. Cell Sci., 121, 2930-2938.

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Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
cytoplasm	during encystation ADI translocates from the cytoplasm to the nucleus	Giardia intestinalis	5737	-
nucleus	during encystation ADI translocates from the cytoplasm to the nucleus	Giardia intestinalis	5634	-

Molecular Weight [Da]

Molecular Weight [Da]	Molecular Weight Maximum [Da]	Comment	Organism
64000	-	estimated from amino acid sequence	Giardia intestinalis
85000	-	sumoylated enzyme	Giardia intestinalis

Organism

Organism	UniProt	Comment	Textmining
Giardia intestinalis	-	-	-

Posttranslational Modification

Posttranslational Modification	Comment	Organism
sumoylation	ADI is also sumoylated, which may modulate its activity	Giardia intestinalis

Source Tissue

Source Tissue	Comment	Organism	Textmining
trophozoite	-	Giardia intestinalis	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
CRGKA + H2O	Giardia lamblia ADI specifically binds to and citrullinates the arginine in the conserved CRGKA tail of variant-specific surface proteins affecting both antigenic switching and antibody mediated cell death	Giardia intestinalis	?	-	?
variant-specific surface protein L-arginine + H2O	-	Giardia intestinalis	variant-specific surface protein L-citrulline + NH3	-	?

Synonyms

Synonyms	Comment	Organism
peptidyl-arginine deiminase	-	Giardia intestinalis

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Release 2023.1 (January 2023)