Activating Compound | Comment | Organism | Structure |
---|---|---|---|
lipid vesicle | binding of substrate myelin basic protein to lipid vesicles, consisting of 7.8% phosphatidylserine and 92.2% phosphatidylcholine, increases deimination activity, but in the 40 amino acid residue C-terminal region, where the arginyl residues are no longer deiminated, while they are deiminated in aqueous solution | Mus musculus |
Protein Variants | Comment | Organism |
---|---|---|
additional information | inactivation of PAD2 does not affect PAD4 activity, but leads to limited deimination due to the narrower cleavage spectrum of arginyl residues in myelin basic protein for PAD4, overview | Mus musculus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
lipid vesicle | binding of substrate myelin basic protein to lipid vesicles, consisting of 7.8% phosphatidylserine and 92.2% phosphatidylcholine, increases deimination activity, but in the 40 mino acid C-terminal region, where the arginyl residues are no longer deiminated, while they are deiminated in aqueous solution; binding of substrate myelin basic protein to lipid vesicles, consisting of 7.8% phosphatidylserine and 92.2% phosphatidylcholine, increases deimination activity, but in the 40 mino acid C-terminal region, where the arginyl residues are no longer deiminated, while they are deiminated in aqueous solution | Mus musculus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytosol | - |
Mus musculus | 5829 | - |
cytosol | PAD2 | Mus musculus | 5829 | - |
nucleus | PAD4 associated with chromatin and with intermediate filaments in the axon | Mus musculus | 5634 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
myelin basic protein-L-arginine + H2O | Mus musculus | - |
myelin basic protein-L-citrulline + NH3 | - |
? | |
myelin basic protein-L-arginine + H2O | Homo sapiens | PAD2 and PAD4 are involved in the pathogenesis of demyelination diseases such as multiple sclerosis, overview | myelin basic protein-L-citrulline + NH3 | - |
? | |
myelin basic protein-L-arginine + H2O | Mus musculus CD-1 | - |
myelin basic protein-L-citrulline + NH3 | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Mus musculus | Q08642 | PAD2; CD-1 mice | - |
Mus musculus | Q9Z183 | PAD4; CD-1 mice | - |
Mus musculus CD-1 | Q08642 | PAD2; CD-1 mice | - |
Mus musculus CD-1 | Q9Z183 | PAD4; CD-1 mice | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
brain | - |
Mus musculus | - |
brain | of healthy persons and of multiple sclerosis patients | Homo sapiens | - |
cerebral white matter | - |
Homo sapiens | - |
cerebral white matter | - |
Mus musculus | - |
myelin sheath | - |
Mus musculus | - |
myelin sheath | quantitative determination of PAD2 and PAD4 by immunohistochemistry | Homo sapiens | - |
oligodendrocyte | - |
Mus musculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
myelin basic protein-L-arginine + H2O | - |
Mus musculus | myelin basic protein-L-citrulline + NH3 | - |
? | |
myelin basic protein-L-arginine + H2O | PAD2 and PAD4 are involved in the pathogenesis of demyelination diseases such as multiple sclerosis, overview | Homo sapiens | myelin basic protein-L-citrulline + NH3 | - |
? | |
myelin basic protein-L-arginine + H2O | amino acid sequence determination of the substrate protein by LC/MS, PAD2 deiminates 18 of 19 arginyl residues, whereas PAD4 deiminates 14 of 19 arginyl residues, determination of deimination residues, overview | Homo sapiens | myelin basic protein-L-citrulline + NH3 | - |
? | |
myelin basic protein-L-arginine + H2O | - |
Mus musculus CD-1 | myelin basic protein-L-citrulline + NH3 | - |
? |
Synonyms | Comment | Organism |
---|---|---|
PAD2 | - |
Homo sapiens |
PAD2 | - |
Mus musculus |
PAD4 | - |
Homo sapiens |
PAD4 | - |
Mus musculus |
peptidylarginine deiminase | - |
Homo sapiens |
peptidylarginine deiminase | - |
Mus musculus |
peptidylarginine deiminase 4 | - |
Homo sapiens |
peptidylarginine deiminase 4 | - |
Mus musculus |