Literature summary for 3.5.3.15 extracted from

Dong, S.; Ying, S.; Kojima, T.; Shiraiwa, M.; Kawada, A.; Mechin, M.C.; Adoue, V.; Chavanas, S.; Serre, G.; Simon, M.; Takahara, H.
Crucial roles of MZF1 and Sp1 in the transcriptional regulation of the peptidylarginine deiminase type I gene (PADI1) in human keratinocytes (2008), J. Invest. Dermatol., 128, 549-557.

Search for more literature for 3.5.3.15

Cloned(Commentary)

Cloned (Comment)	Organism
promoter sequence determination and anaylsis 195 base pairs upstream from the transcription initiation site, primer extension method and determination of minimal promoter sequence, the promoter activity depends on MFZ1 and Sp1/Sp3 binding to their specific sites	Homo sapiens

Protein Variants

Protein Variants	Comment	Organism
additional information	the promoter activity of MFZ1- and Sp1-binding site mutants is reduced, overview	Homo sapiens

Metals/Ions

Metals/Ions	Comment	Organism	Structure
Ca2+	required for activity, calcium increases the expression of PAD1 and PAD2	Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
keratin-L-arginine + H2O	Homo sapiens	PAD1	keratin-L-citrulline + NH3	-	ir
protein-L-arginine + H2O	Homo sapiens	-	protein-L-citrulline + NH3	-	ir

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	Q9ULC6	isozyme PAD1	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
epidermis	isozyme PAD1	Homo sapiens	-
HeLa cell	low expression level of PAD1	Homo sapiens	-
keratinocyte	epidermal, isozyme PAD1, PAD1 and MFZ1 increase both during differentiation	Homo sapiens	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
keratin-L-arginine + H2O	PAD1	Homo sapiens	keratin-L-citrulline + NH3	-	ir
protein-L-arginine + H2O	-	Homo sapiens	protein-L-citrulline + NH3	-	ir

Synonyms

Synonyms	Comment	Organism
PADI1	-	Homo sapiens
peptidylarginine deiminase type I	-	Homo sapiens

Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.

Release 2023.1 (January 2023)