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Literature summary for 3.5.3.15 extracted from

  • Bhattacharya, S.K.; Crabb, J.S.; Bonilha, V.L.; Gu, X.; Takahara, H.; Crabb, J.W.
    Proteomics implicates peptidyl arginine deiminase 2 and optic nerve citrullination in glaucoma pathogenesis (2006), Invest. Ophthalmol. Vis. Sci., 47, 2508-2514.
    View publication on PubMed
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Mus musculus proteomics implicates peptidyl arginine deiminase 2 and optic nerve citrullination in glaucoma pathogenesis. Pressure-induced translational control of PAD2 expression is consistent with a possible role for PAD2 and citrullination in primary open-angle glaucoma ?
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Organism

Organism UniProt Comment Textmining
Mus musculus Q08642
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Source Tissue

Source Tissue Comment Organism Textmining
astrocyte pressure-treated astrocytes exhibit elevated PAD2 and citrullination without apparent change in PAD2 mRNA Mus musculus
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optic nerve from older, glaucomatous DBA/2J mice (primary open-angle glaucoma), but not in younger DGB/2J or control C57BL6J mice Mus musculus
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information proteomics implicates peptidyl arginine deiminase 2 and optic nerve citrullination in glaucoma pathogenesis. Pressure-induced translational control of PAD2 expression is consistent with a possible role for PAD2 and citrullination in primary open-angle glaucoma Mus musculus ?
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 ?
myelin basic protein L-arginine + H2O
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 Mus musculus myelin basic protein L-citrulline + NH3
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 ?

Synonyms

Synonyms Comment Organism
PAD2
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 Mus musculus