Literature summary for 3.5.3.11 extracted from

Bernstein, H.G.; Derst, C.; Stich, C.; Pruess, H.; Peters, D.; Krauss, M.; Bogerts, B.; Veh, R.W.; Laube, G.
The agmatine-degrading enzyme agmatinase: a key to agmatine signaling in rat and human brain? (2010), Amino Acids, 40, 453-465.

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Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
agmatine + H2O	Homo sapiens	-	putrescine + urea	-	?
agmatine + H2O	Rattus norvegicus	-	putrescine + urea	-	?

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-
Rattus norvegicus	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
brain	-	Homo sapiens	-
brain	-	Rattus norvegicus	-
neuron	agmatinase is predominantly detected in distinct populations of neurons, especially cortical interneurons. Principal neurons in limbic regions like the habenula and in the cerebellum robustly express agmatinase protein	Homo sapiens	-
neuron	agmatinase is predominantly detected in distinct populations of neurons, especially cortical interneurons. Principal neurons in limbic regions like the habenula and in the cerebellum robustly express agmatinase protein	Rattus norvegicus	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
agmatine + H2O	-	Homo sapiens	putrescine + urea	-	?
agmatine + H2O	-	Rattus norvegicus	putrescine + urea	-	?

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Release 2023.1 (January 2023)