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Literature summary for 3.5.3.1 extracted from

  • Ilies, M.; Di Costanzo, L.; North, M.L.; Scott, J.A.; Christianson, D.W.
    2-aminoimidazole amino acids as inhibitors of the binuclear manganese metalloenzyme human arginase I (2010), J. Med. Chem., 53, 4266-4276.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

Cloned (Comment) Organism
-
Mus musculus
-
Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
(2S)-2-amino-3-(2-amino-1H-imidazol-5-yl)propanoic acid 2-aminoimidazole amino acid inhibitor in which the 2-aminoimidazole moiety serves as a guanidine mimetic Homo sapiens
(2S)-2-amino-3-(2-amino-1H-imidazol-5-yl)propanoic acid 2-aminoimidazole amino acid inhibitor in which the 2-aminoimidazole moiety serves as a guanidine mimetic, significantly attenuates airways hyperresponsiveness in a murine model of allergic airways inflammation Mus musculus
(2S)-2-amino-5-(1H-imidazol-2-ylamino)pentanoic acid 2-aminoimidazole amino acid inhibitor in which the 2-aminoimidazole moiety serves as a guanidine mimetic Homo sapiens
2-(S)-amino-5-(2-aminoimidazol-1-yl)pentanoic acid 2-aminoimidazole amino acid inhibitor in which the 2-aminoimidazole moiety serves as a guanidine mimetic Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens P05089
-
-
Mus musculus
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-arginine + H2O
-
Mus musculus L-ornithine + urea
-
?
L-arginine + H2O
-
Homo sapiens L-ornithine + urea
-
?

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.004
-
2-(S)-amino-5-(2-aminoimidazol-1-yl)pentanoic acid pH not specified in the publication, temperature not specified in the publication Homo sapiens
0.3
-
(2S)-2-amino-3-(2-amino-1H-imidazol-5-yl)propanoic acid pH not specified in the publication, temperature not specified in the publication Homo sapiens
0.5
-
(2S)-2-amino-5-(1H-imidazol-2-ylamino)pentanoic acid pH not specified in the publication, temperature not specified in the publication Homo sapiens