Literature summary for 3.5.3.1 extracted from

Chrzanowska, A.; Gajewska, B.; Baranczyk-Kuzma, A.
Arginase isoenzymes in human cirrhotic liver (2009), Acta Biochim. Pol., 56, 465-469.

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Application

Application	Comment	Organism
medicine	a significant decrease in arginase activity, dependent of the liver clinical stage, is observed in cirrhotic tissue. Arginase AI activity and its mRNA level are significantly decreased in cirrhotic liver, whereas the activity and expression of arginase AII are concurrently raised, as compared to normal liver	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	P78540	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
liver	-	Homo sapiens	-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg]	Specific Activity Maximum [µmol/min/mg]	Comment	Organism
41.8	888.5	range of activity in cirrhotic liver, 37°C, pH not specified in the publication	Homo sapiens
860.4	2300	range of activity in healthy liver, 37°C, pH not specified in the publication	Homo sapiens

Expression

Organism	Comment	Expression
Homo sapiens	arginase AI activity and its mRNA level are significantly decreased in cirrhotic liver	down
Homo sapiens	arginase AII activity and its mRNA level are significantly raised in cirrhotic liver	up

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Release 2023.1 (January 2023)