Literature summary for 3.5.3.1 extracted from

Lerzynski, G.; Suschek, C.V.; Kolb-Bachofen, V.
In hepatocytes the regulation of NOS-2 activity at physiological L-arginine levels suggests a close link to the urea cycle (2006), Nitric Oxide, 14, 300-308.

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Inhibitors

Inhibitors	Comment	Organism	Structure
L-valine	-	Rattus norvegicus

Organism

Organism	UniProt	Comment	Textmining
Rattus norvegicus	P07824	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
hepatocyte	24h culture, both enzyme and NOS-2 activity depend strongly on extracellular L-arginine concentrations. Competing for L-arginine influx by addition of L-lysine results in 60-70% inhibition of enzyme. Addition of enzyme inhibitor L-valine to cells leads to 80-90% decrease in enzyme activity and 25% increase in NOS-2 activity	Rattus norvegicus	-

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Release 2023.1 (January 2023)