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Literature summary for 3.5.3.1 extracted from

  • Topal, J.L.; Brunet, A.; Walch, L.; Boucher, J.L.; David-Dufilho, M.
    Mitochondrial arginase II modulates nitric-oxide synthesis through nonfreely exchangeable L-arginine pools in human endothelial cells (2006), J. Pharmacol. Exp. Ther., 318, 1368-1374.
    View publication on PubMed
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Inhibitors

Inhibitors Comment Organism Structure
Nomega-hydroxy-nor-L-arginine in unstimulated HUVEC cells, dose-dependent reduction of enzyme activity, maximum inhibition at 0.02 mM. In cells stimulated by thrombin with or without extracellular L-arginine, stimulation of NO synthase and NO release, with significant reduction of enzyme activity Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol enzyme is barely detectable Homo sapiens 5829
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mitochondrion constitutive expression of enzyme Homo sapiens 5739
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens presence of arginine pools, which are accessible to NO synthase and enzyme, but not exchangeable ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
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-
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Source Tissue

Source Tissue Comment Organism Textmining
HUVEC cell
-
 Homo sapiens
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information presence of arginine pools, which are accessible to NO synthase and enzyme, but not exchangeable Homo sapiens ?
-
 ?