Literature summary for 3.5.3.1 extracted from

McGee, D.J.; Kumar, S.; Viator, R.J.; Bolland, J.R.; Ruiz, J.; Spadafora, D.; Testerman, T.L.; Kelly, D.J.; Pannell, L.K.; Windle, H.J.
Helicobacter pylori thioredoxin is an arginase chaperone and guardian against oxidative and nitrosative stresses (2006), J. Biol. Chem., 281, 3290-3296.

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Activating Compound

Activating Compound	Comment	Organism	Structure
Trx1	thioredoxin Trx1, stimulation by acting as a chaperone	Helicobacter pylori

Inhibitors

Inhibitors	Comment	Organism	Structure
diethylene triamine-nitric oxide	50% inhibition at 2 mM	Helicobacter pylori
hydrogen peroxide	50% inhibition at 0.003 mM	Helicobacter pylori
S-nitrosoglutathione	50% inhibition at 0.050 mM	Helicobacter pylori
sodium nitroprusside	50% inhibition at 0.005 mM	Helicobacter pylori

Organism

Organism	UniProt	Comment	Textmining
Helicobacter pylori	-	-	-

Renatured (Commentary)

Renatured (Comment)	Organism
renaturation of heat- or urea-denatured enzyme by chaperone thioredoxin Trx1 from Helicobacter pylori extracts	Helicobacter pylori

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Release 2023.1 (January 2023)