Literature summary for 3.5.3.1 extracted from

Shin, H.; Cama, E.; Christianson, D.W.
Design of amino acid aldehydes as transition-state analogue inhibitors of arginase (2004), J. Am. Chem. Soc., 126, 10278-10284.

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Crystallization (Commentary)

Crystallization (Comment)	Organism
isoform arginase I in complex with inhibitor (S)-2-amino-7-oxoheptanoic acid. Inhibitor aldehyde moiety is hydrated to form the gem-diol, one hydroxyl group bridges the Mn2+ cluster and donates a hydrogen bond to D128, and the second hydroxyl group donates a hydrogen bond to E277	Rattus norvegicus

Inhibitors

Inhibitors	Comment	Organism	Structure
(2S,5E)-2-amino-7-oxohept-5-enoic acid	-	Rattus norvegicus
(S)-2-amino-7-oxoheptanoic acid	-	Rattus norvegicus

Organism

Organism	UniProt	Comment	Textmining
Rattus norvegicus	-	recombinant enzyme	-

Ki Value [mM]

Ki Value [mM]	Ki Value maximum [mM]	Inhibitor	Comment	Organism	Structure
0.06	-	(S)-2-amino-7-oxoheptanoic acid	pH 9.5	Rattus norvegicus
0.36	-	(2S,5E)-2-amino-7-oxohept-5-enoic acid	pH 9.5	Rattus norvegicus

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Release 2023.1 (January 2023)