Literature summary for 3.5.3.1 extracted from

Zhang, C.; Hein, T.W.; Wang, W.; Miller, M.W.; Fossum, T.W.; McDonald, M.M.; Humphrey, J.D.; Kuo, L.
Upregulation of vascular arginase in hypertension decreases nitric oxide-mediated dilation of coronary arterioles (2004), Hypertension, 44, 935-943.

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Application

Application	Comment	Organism
medicine	in coronary arteriole, enzyme activity increases twofold with hypertension. Inhibition of enzyme activity by Nomega-hydroxy-nor-L-arginine or incubation with L-arginine partially restores NO release and dilation to adenosine in hypertrophic vessels	Sus scrofa

Inhibitors

Inhibitors	Comment	Organism	Structure
Nomega-hydroxy-nor-L-arginine	-	Sus scrofa

Organism

Organism	UniProt	Comment	Textmining
Sus scrofa	-	with hypertension due to aortic coarctation	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
arteriole	coronary arteriole, enzyme activity increases twofold with hypertension. Inhibition of enzyme activity by Nomega-hydroxy-nor-L-arginine or incubation with L-arginine partially restores NO release and dilation to adenosine in hypertrophic vessels	Sus scrofa	-

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Release 2023.1 (January 2023)