Inhibitors | Comment | Organism | Structure |
---|---|---|---|
Al3+ | no inhibition of isozyme I, 33% inhibition of isozyme II | Rattus norvegicus | |
Cd2+ | 10% inhibition of isozyme I, 86% inhibition of isozyme II | Rattus norvegicus | |
Cu2+ | 56% inhibition of isozyme I, 69% inhibition of isozyme II, non-linear allosteric inhibition for isozymes I and II, inhibition is increased with isozyme I by preincubation with the metal ions, not with isozyme II | Rattus norvegicus | |
Fe3+ | 12% inhibition of isozyme I, 36% inhibition of isozyme II | Rattus norvegicus | |
Hg2+ | 80% inhibition of isozyme I, 96% inhibition of isozyme II, non-linear allosteric inhibition for isozymes I and II, inhibition is increased with isozyme I by preincubation with the metal ions, not with isozyme II | Rattus norvegicus | |
additional information | effect of preincubation of the isozymes with metal ions, overview | Rattus norvegicus | |
Ni2+ | no inhibition of isozyme I, 11% inhibition of isozyme II | Rattus norvegicus | |
Pb2+ | 74% inhibition of isozyme I, 92% inhibition of isozyme II | Rattus norvegicus | |
Zn2+ | 13% inhibition of isozyme I, 75% inhibition of isozyme II | Rattus norvegicus |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Co2+ | activates isozyme II 1.46fold, no activation of isozyme I | Rattus norvegicus | |
Mn2+ | dependent on, manganese-metalloenzyme, activates isozyme I, slightly, and isozyme II | Rattus norvegicus | |
additional information | isozymes are not affected by Mg2+ and Ca2+ | Rattus norvegicus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
kidney | isozyme II | Rattus norvegicus | - |
liver | isozyme I | Rattus norvegicus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-arginine + H2O | - |
Rattus norvegicus | L-ornithine + urea | - |
? |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Rattus norvegicus |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7 | - |
assay at | Rattus norvegicus |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
additional information | - |
additional information | inhibition kinetics | Rattus norvegicus |