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Literature summary for 3.5.3.1 extracted from
- Synthesis and evaluation of alternative substrates for arginase (2002), Bioorg. Chem., 30, 81-94.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| 2-amino-6-boronohexanoic acid | - |
Rattus norvegicus |  |
| Boric acid | - |
Rattus norvegicus | |
| additional information | isothiourea homologues undergo rapid non-enzymic rearrangement to probably give inhibitory compouds, overview | Rattus norvegicus |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.007 | - |
4-guanidino-3-nitrobenzoic acid | pH 9.0 | Rattus norvegicus | |
| 0.01 | - |
4-guanidino-2-nitrophenylacetic acid | pH 9.0 | Rattus norvegicus | |
| 0.5 | - |
L-thioarginine | pH 9.0 | Rattus norvegicus | |
| 1.4 | - |
L-arginine | pH 9.0 | Rattus norvegicus | |
| 1.6 | - |
1-nitro-3-guanidinobenzene | pH 9.0 | Rattus norvegicus | |
| 2.1 | - |
thioguanidino-valeric acid | pH 9.0 | Rattus norvegicus | |
| 4 | - |
S-(4-aminobutyl)isothiourea | pH 9.0 | Rattus norvegicus | |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Mn2+ | - |
Rattus norvegicus | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| L-arginine + H2O | Rattus norvegicus | - |
L-ornithine + urea | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Rattus norvegicus | - |
- |
- |
Reaction
| Reaction | Comment | Organism | Reaction ID |
|---|---|---|---|
| L-arginine + H2O = L-ornithine + urea | Asn130 and Ser137 are involved in substrate binding and catalysis | Rattus norvegicus |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| liver | - |
Rattus norvegicus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 1-nitro-3-guanidinobenzene + H2O | synthetic chromophoric substrate, low activity | Rattus norvegicus | 3-nitrobenzenamine + urea | - |
? | |
| 4-guanidino-2-nitrophenylacetic acid + H2O | - |
Rattus norvegicus | 4-amino-2-nitrophenylacetate + urea | - |
? | |
| 4-guanidino-3-nitrobenzoic acid + H2O | - |
Rattus norvegicus | 4-amino-3-nitrobenzoate + urea | - |
? | |
| L-arginine + H2O | - |
Rattus norvegicus | L-ornithine + urea | - |
? | |
| L-thioarginine + H2O | - |
Rattus norvegicus | (2S)-2-amino-5-mercaptopentanoate + urea | - |
? | |
| S-(4-aminobutyl)isothiourea + H2O | - |
Rattus norvegicus | ? | - |
? | |
| thioguanidino-valeric acid + H2O | - |
Rattus norvegicus | ? | - |
? | |
Turnover Number [1/s]
| Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.0015 | - |
1-nitro-3-guanidinobenzene | pH 9.0 | Rattus norvegicus | |
| 0.013 | - |
thioguanidino-valeric acid | pH 9.0 | Rattus norvegicus | |
| 0.058 | - |
4-guanidino-3-nitrobenzoic acid | pH 9.0 | Rattus norvegicus | |
| 0.09 | - |
4-guanidino-2-nitrophenylacetic acid | pH 9.0 | Rattus norvegicus | |
| 3.33 | - |
S-(4-aminobutyl)isothiourea | pH 9.0 | Rattus norvegicus | |
| 250 | - |
L-arginine | pH 9.0 | Rattus norvegicus | |
| 300 | - |
L-thioarginine | pH 9.0 | Rattus norvegicus | |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 9 | - |
assay at | Rattus norvegicus |
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