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Literature summary for 3.5.3.1 extracted from

  • Colleluori, D.M.; Morris, S.M., Jr.; Ash, D.E.
    Expression, purification, and characterization of human type II arginase (2001), Arch. Biochem. Biophys., 389, 135-143.
    View publication on PubMed
Search for more literature for 3.5.3.1

Application

Application Comment Organism
medicine enzyme is a target for inhibitors used in therapeutic treatment of smooth muscle disorders, such as erectile dysfunction Homo sapiens

Cloned(Commentary)

Cloned (Comment) Organism
expression in Escherichia coli Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
Borate noncompetitive Homo sapiens
additional information ornithine is a poor inhibitor of isozyme type II, isozyme selectivity in binding and substrate, products, and inhibitors Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
4.8
-
 L-arginine about pH 7.0 Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrion
-
 Homo sapiens 5739
-
additional information extrahepatic Homo sapiens
-
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
L-arginine + H2O Homo sapiens enzyme is involved in net production of ornithine, a precursor of polyamines, glutamate, and proline, enzyme is also involved in regulation of nitric oxide biosynthesis by modulating arginine availability for nitric oxide synthase L-ornithine + urea
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
 isozyme type II
-

Purification (Commentary)

Purification (Comment) Organism
recombinant enzyme to homogeneity Homo sapiens

Reaction

Reaction Comment Organism Reaction ID
L-arginine + H2O = L-ornithine + urea also hydrolyses alpha-N-substituted L-arginines and canavanine Homo sapiens
a

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-arginine + H2O
-
 Homo sapiens L-ornithine + urea
-
 ?
L-arginine + H2O enzyme is involved in net production of ornithine, a precursor of polyamines, glutamate, and proline, enzyme is also involved in regulation of nitric oxide biosynthesis by modulating arginine availability for nitric oxide synthase Homo sapiens L-ornithine + urea
-
 ?
additional information isozyme selectivity in binding and substrate, products, and inhibitors Homo sapiens ?
-
 ?

Subunits

Subunits Comment Organism
trimer primarily, higher order oligomers are also observed Homo sapiens

Synonyms

Synonyms Comment Organism
type II arginase
-
 Homo sapiens

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.3
-
 Borate
-
 Homo sapiens