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Literature summary for 3.5.2.9 extracted from
- Glutamine affects glutathione recycling enzymes in a DMBA-induced breast cancer model (2008), Nutr. Cancer, 60, 518-525.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| L-glutamine | enhanced enzyme activity in jejunal mucosa of tumor-bearing rats | Rattus norvegicus |  |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| L-glutamine | inhibition of enzyme activity in tumor tissue | Rattus norvegicus | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Rattus norvegicus | - |
Sprague-Dawley rats, female | - |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| breast cancer cell | - |
Rattus norvegicus | - |
| jejunal mucosa | - |
Rattus norvegicus | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| 1 | - |
measured in tumor tissue after treatment with dietary glutamine | Rattus norvegicus |
| 1.25 | - |
measured in jejunal mucosa in DMBA-teated rats with tumor | Rattus norvegicus |
| 2.5 | - |
measured in tumor tissue | Rattus norvegicus |
| 2.91 | - |
measured in jejunal mucosa in DMBA-treated rats without tumor | Rattus norvegicus |
| 3 | - |
measured in jejunal mucosa after treatment with dietary glutamine in DMBA-treated rats without tumor | Rattus norvegicus |
| 3.75 | - |
measured in jejunal mucosa in normal rats | Rattus norvegicus |
| 4.17 | - |
measured in jejunal mucosa after treatment with dietary glutamine in normal rats | Rattus norvegicus |
| 4.33 | - |
measured in jejunal mucosa after treatment with dietary glutamine in DMBA-treated rats with tumor | Rattus norvegicus |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 5-oxo-L-proline + ATP + 2 H2O | assay at pH 7.2, 5 mM substrate, 4°C, 20 min | Rattus norvegicus | L-glutamate + phosphate + ADP | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| 5-oxo-L-prolinase | - |
Rattus norvegicus |
| OPase | - |
Rattus norvegicus |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 4 | - |
assay at | Rattus norvegicus |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7.2 | - |
assay at | Rattus norvegicus |
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