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Literature summary for 3.5.2.9 extracted from
- Activity and distribution of the cysteine prodrug activating enzyme, 5-oxo-L-prolinase, in human normal and tumor tissues (1997), Cancer Lett., 117, 105-111.
Application
| Application | Comment | Organism |
|---|---|---|
| medicine | reduces normal tissue toxicity of anticancer agents | Homo sapiens |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 5-oxo-L-proline + H2O + ATP | Homo sapiens | - |
L-glutamate + ADP + phosphate | - |
? |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
human | - |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| breast | normal and cancer tissues | Homo sapiens | - |
| colon | normal and cancer tissues | Homo sapiens | - |
| ovary | normal and cancer tissues | Homo sapiens | - |
Storage Stability
| Storage Stability | Organism |
|---|---|
| -70°C, no loss of activity detected | Homo sapiens |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 5-oxo-L-proline + H2O + ATP | - |
Homo sapiens | L-glutamate + ADP + phosphate | - |
? | |
| L-2-oxothiazolidine-4-carboxylate + H2O + ATP | - |
Homo sapiens | L-cysteine + ADP + phosphate | - |
? | |
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