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Literature summary for 3.5.2.6 extracted from

  • Wei, D.D.; Wan, L.G.; Yu, Y.; Xu, Q.F.; Deng, Q.; Cao, X.W.; Liu, Y.
    Characterization of extended-spectrum beta-lactamase, carbapenemase, and plasmid quinolone determinants in Klebsiella pneumoniae isolates carrying distinct types of 16S rRNA methylase genes, and their association with mobile genetic elements (2015), Microb. Drug Resist., 21, 186-193 .
    View publication on PubMed
Search for more literature for 3.5.2.6

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
amikacin + H2O Klebsiella pneumoniae
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 ?
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 ?
imipenem + H2O Klebsiella pneumoniae
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 (5R)-3-[[2-(carbonoimidoylamino)ethyl]sulfanyl]-5-[(1S,2R)-1-carboxy-2-hydroxypropyl]-4,5-dihydro-1H-pyrrole-2-carboxylic acid
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 ?

Organism

Organism UniProt Comment Textmining
Klebsiella pneumoniae C7C422 gene blaNDM-1; 84 multidrug-resistant Klebsiella pneumoniae (MDR-KP) isolates from a chinese hospital from January to October 2012
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Klebsiella pneumoniae Q2PUH3 gene blaCTX-M-15; 84 multidrug-resistant Klebsiella pneumoniae (MDR-KP) isolates from a chinese hospital from January to October 2012
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Klebsiella pneumoniae Q48434 gene blaCMY-2; 84 multidrug-resistant Klebsiella pneumoniae (MDR-KP) isolates from a chinese hospital from January to October 2012
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Klebsiella pneumoniae Q4LDF1 gene blaIMP-4; 84 multidrug-resistant Klebsiella pneumoniae (MDR-KP) isolates from a chinese hospital from January to October 2012
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Klebsiella pneumoniae Q93LQ9 gene blaKPC-2; 84 multidrug-resistant Klebsiella pneumoniae (MDR-KP) isolates from a chinese hospital from January to October 2012
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
amikacin + H2O
-
 Klebsiella pneumoniae ?
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 ?
imipenem + H2O
-
 Klebsiella pneumoniae (5R)-3-[[2-(carbonoimidoylamino)ethyl]sulfanyl]-5-[(1S,2R)-1-carboxy-2-hydroxypropyl]-4,5-dihydro-1H-pyrrole-2-carboxylic acid
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 ?
additional information in vitro activity of 13 antimicrobial agents against 19 multidrug-resistant Klebsiella pneumoniae amikacin resistance isolates, overview Klebsiella pneumoniae ?
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Synonyms

Synonyms Comment Organism
blaCMY-2
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 Klebsiella pneumoniae
blaCTX-M-15
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 Klebsiella pneumoniae
blaIMP-4
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 Klebsiella pneumoniae
blaKPC-2
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 Klebsiella pneumoniae
blaNDM-1
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 Klebsiella pneumoniae
carbapenemase
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 Klebsiella pneumoniae
metallo-beta-lactamase type 2 UniProt Klebsiella pneumoniae

General Information

General Information Comment Organism
additional information close to 80% of blaTEM-1 and blaSHV-12 are linked to IS26 while 90% or more of blaCTX-Ms and blaCMYs are linked to ISEcp1. ISAba125 is located upstream of blaNDM-1 and some blaCMY-2 genes. In addition, seven transconjugants are available for further analysis, and armA, qnrS1, acc(6')-Ib-cr, blaCTX-M-15, blaTEM-1, and blaNDM-1 are cotransferred. The dissemination of 16S rRNA methylase genes and the prevalence of selected elements implicated in evolution of antibiotics resistance determinants in collection of clinical Klebsiella pneumoniae in China, overview Klebsiella pneumoniae
physiological function 84 multidrug-resistant Klebsiella pneumoniae (MDR-KP) clinical isolates studied, 19 isolates exhibit high level resistance to amikacin mediated by the production of the 16S rRNA methylase. CTX-M genes were found in all of the isolates. Among these armA- or rmtB/CTX-M-producing Klebsiella pneumoniae isolates, 31.6% carry the carbapenemase genes (blaKPC-2 [26.3%], blaIMP-4 [10.5%], and blaNDM-1 [5.3%]), which made them resistant to imipenem Klebsiella pneumoniae