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Literature summary for 3.5.2.6 extracted from

  • Yi, H.; Cho, K.H.; Cho, Y.S.; Kim, K.; Nierman, W.C.; Kim, H.S.
    Twelve Positions in a beta-lactamase that can expand its substrate spectrum with a single amino acid substitution (2012), PLoS ONE, 7, e37585.
    View publication on PubMedView publication on EuropePMC

Protein Variants

Protein Variants Comment Organism
additional information analysis of 516 mutated enzymes that acquired the ceftazidime-hydrolyzing activity, and identification of twelve positions with single amino acid substitutions, co-localized at the active-site pocket area. single amino acid substitutions are found at positions C89, N136, L162, R164, E166, L169, N170, T171, A172, P174, D176, D179. All substitutions cause a congruent effect, expanding the space in a conserved structure called the omega loop, which in turn increased flexibility at the active site Burkholderia thailandensis

Organism

Organism UniProt Comment Textmining
Burkholderia thailandensis
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Synonyms

Synonyms Comment Organism
PenA
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Burkholderia thailandensis